Figge J. Role of Non-Volatile Weak Acids (Albumin, Phosphate and Citrate). In Stewart's Textbook of Acid-Base. Kellum JA and Elbers PWG, editors. Amsterdam: 2009. Chapter 11, pages 217 - 232.

Chapter 11

Figure 11.1

Figure 11.1

Figure 11.1. Predicted titration curve of human serum albumin at 37 oC and ionic strength of approximately 0.15 over the pH range 5.0 to 9.0, as calculated by the Figge-Fencl model (smooth curve). Predicted charge displayed by albumin is given in Eq / mol albumin. The predicted isoelectric point is at pH = 5.48. The independent experimental data points of Fogh-Andersen, Bjerrum and Siggaard-Andersen [from Figure 4 in reference 9] are also shown (diamonds). These experimental data points give the intrinsic charge carried by human albumin at 37 oC in the presence of physiologic concentrations of NaCl, KCl, and CaCl2. Note the close agreement between the titration curve predicted by the Figge-Fencl model and the independent experimental data points of Fogh-Andersen and colleagues.

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