Figge J. Role of Non-Volatile Weak Acids (Albumin, Phosphate and Citrate). In Stewart's
Textbook of Acid-Base. Kellum JA and Elbers PWG, editors. Amsterdam: AcidBase.org. 2009.
Chapter 11, pages 217 - 232.
Graphic results of a computer simulation in which the Figge-Fencl model is used to
demonstrate the effect of varying [SID], PCO2, and [Albumin] in plasma-like solutions
containing albumin as the sole protein moiety. The simulation in Figure 3 is run using
[Albumin] = 22 g / L (2.2 g / dL) (compare with Figure 11.2). The SID ranges from 20 to 50 mEq / L,
and results are plotted with three different values of PCO2 (upper dotted curve = 20 mm Hg,
middle dashed curve = 40 mm Hg, and lower solid curve = 60 mm Hg). Note that all three curves shift
upward to higher pH values when the concentration of albumin is decreased from 44 g / L (Figure 11.2)
to 22 g / L.